Multidisciplinary Management of Salivary Gland Cancers.

نویسندگان

  • Matthew J Mifsud
  • Jon N Burton
  • Andy M Trotti
  • Tapan A Padhya
چکیده

BACKGROUND Salivary carcinomas are a rare group of biologically diverse neoplasms affecting the head and neck. The wide array of different histological entities and clinical presentations has historically limited attempts to establish well-defined treatment algorithms. In general, low-risk lesions can be managed with a single treatment modality, whereas advanced lesions require a more complex, multidisciplinary approach. METHODS The relevant literature was reviewed, focusing on diagnostic and treatment algorithms for salivary malignancies. RESULTS Salivary carcinomas with high-risk features require an aggressive treatment approach with complete surgical resection, neck dissection to appropriate cervical lymph-node basins, and postoperative radiotherapy. CONCLUSIONS The heterogeneity of salivary neoplasms represents a unique clinical challenge. Despite the multidisciplinary management paradigm detailed in this review, outcomes for advanced disease are unsatisfactory. Future progress will likely require the addition of novel systemic therapeutic strategies.

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عنوان ژورنال:
  • Cancer control : journal of the Moffitt Cancer Center

دوره 23 3  شماره 

صفحات  -

تاریخ انتشار 2016